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FOCUS Quiz: Spring 2018 - Biomarkers in Psychiatry

Activity Type:

  • Journal CME

Release Date: 4/1/2019

Expiration Date: 12/31/2020

  • AMA PRA Category 1 Physician: 5
  • Participation: 5



Biomarkers in Psychiatry

FOCUS, APA's clinical review and continuing medical education journal, is designed as a personal study resource to help practicing psychiatrists keep abreast of significant advances in the field, with particular attention to clinical practice and incorporation of core competencies. The goal of FOCUS is the dissemination of up-to-date clinical information, facilitation of lifelong learning skills, maintenance of certification, and opportunity for self-assessment in order to improve patient care. Each issue, prepared by distinguished faculty who are recognized in their fields, provides up to date clinical information and incorporates a CME component. The material can be used effectively by establishing a regular schedule of study.


This activity is only available to 2018 Focus subscribers.

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Educational Objectives

As a result of this activity, participants will:

Familiarize themselves with

  • the methods for developing and evaluating biomarkers in psychiatry
  • the strengths and limitations of biomarkers in clinical practice, and
  • the conditions and contexts that form the basis for obtaining valid and useful results with biomarkers in  psychiatry

Review the types of bio-measures and biomarkers, as well as the clinical uses and the challenges to be faced in the development and clinical use of biomarkers

Target Audience

This program is one element of a lifelong learning program for psychiatrists and is an aid for psychiatrists and other clinicians participating in maintenance of certification.

Estimated Time to Complete

Estimated Duration: 5 hours
Begin Date: April 1, 2018
End Date: December 31, 2020

How to Earn Credit

In order to earn CME credit, participants should read through the material presented in the issue. After reading the materials, complete the CME quiz by answering multiple-choice questions with a single correct answer. A score of 60% or higher is required to receive credit. Retakes are available for the test. Review the rationales, complete the online course evaluation, and then claim and print your CME certificate. The APA provides a CME certificate of credit for physicians and a certificate of participation for non-physicians.

Continuing Education Credit

The American Psychiatric Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The APA designates this journal-based CME activity for a maximum of 5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Faculty and Planner Disclosures

Program Planners – Editor and Associate Editors and Guest Editors

Mark H. Rapaport, M.D., Editor of FOCUS, and Chairman and Chief of Psychiatric Services, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Ga. No financial relationships with commercial interests.

Dorothy Stubbe, M.D., Editor Communications Commentary, Associate Professor and Program Director, Yale University School of Medicine Child Study Center, New Haven, CT.- No financial relationships with commercial interests.

Laura Dunn, M.D., Co-Editor Ethics Column; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA; Dr. Dunn reports: Consultant: Otsuka America Pharmaceutical Inc.

Guest Editor: A John Rush M.D., Prof Emeritus, Duke-NUS, Adj Prof, Duke Med Sch, Adj Prof, Texas Tech, and CEO Curbstone Consultant: provides in-depth consultation and mentoring of academic career development, research design, grant proposal and protocol development, research project implementation, data analysis, scientific publications and research team formation and management. Customers include individuals, as well as industrial, academic, governmental and not-for-profit entities.  Dr. Rush has received consulting fees from Akili, Brain Resource Inc., Compass Inc., Curbstone Consultant LLC, Eli Lilly, Emmes Corp, Liva-Nova, Mind Linc., Sunovion, Takeda USA, Taj Medical; speaking fees from Liva-Nova and Sing-Health; and royalties from Guilford Press and the University of Texas Southwestern Medical Center, Dallas, TX. (for the Inventory of Depressive Symptoms and its derivatives).  He is also named co-inventor on two patents, from which no income is derived: U.S. Patent No. 7,795,033: Methods to Predict the Outcome of Treatment with Antidepressant Medication, Inventors: McMahon FJ, Laje G, Manji H, Rush AJ, Paddock S, Wilson AS and U.S. Patent No. 7,906,283: Methods to Identify Patients at Risk of Developing Adverse Events During Treatment with Antidepressant Medication, Inventors: McMahon FJ, Laje G, Manji H, Rush AJ, Paddock S.

FOCUS Author Affiliation and Disclosure Information

Hicham M. Ibrahim, M.D., Associate Professor, Dept. of Psychiatry, University of Texas, Southwestern Medical Center, Dallas, TX. Reports no financial relationships with commercial interests.

Ami Klin M.D., Division of Autism & Related Disabilities, Department of Pediatrics, Emory University School of Medicine, Atlanta, George, and the Marcus Autism Center, Children’s Healthcare of Atlanta. Reports no financial relationships with commercial interests.

Charles Reynolds M.D., Distinguished Professor of Psychiatry (emeritus) at the University of Pittsburgh School of Medicine, Pittsburgh. Dr. Reynolds is a coinventor of the psychometric analysis (licensed intellectual property) of the Pittsburgh Sleep Quality Index and receives royalties for its use.

Tom Insel M.D., Former director of NIMH. Dr. Insel is employed by Mindstrong Health, LLC (Palo Alto, CA, USA). Stock: Alkermes, Alphabet, Apple, Microsoft, Mindstrong, Sage; Consultant: Compass Pathways, Inscopix, 7 Cups; Employee: Mindstrong Health

David R. Goldsmith, M.D., Courtney L. Crooks, Ph.D., Elaine F. Walker, Ph.D., Robert O. Cotes, M.D. Dr. Goldsmith, Dr. Crooks, and Dr. Cotes are with the Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Dr. Walker is with the Department of Psychology, Emory University. Dr. Goldsmith and Cotes received research funding from Otsuka Pharmaceutical and Alkermes. Dr. Cotes is on a speakers’ bureau for Otsuka Pharmaceutical and participated in an advisory panel for Alkermes. Dr Walker reports no conflicts.

Aaron M. Koenig, M.D., Chloe K. Nobuhara, B.S., Victoria J. Williams, Ph.D., Steven E. Arnold, M.D. All authors, at the time the manuscript was submitted are with the Mass General Institute for Neurodegenerative Disease (MIND), Department of Neurology, Massachusetts General Hospital, Boston.  More recently, Dr. Koenig reports that he is currently an employee of Biogen and owns stock in Biogen. Ms. Nobuhara reports no financial relationships with commercial interests. Dr. Williams reports no financial relationships with commercial interests. Dr. Arnold reports grant support, advisory panel or consulting interests with the National Institutes of Health, Abbvie, Amylyx, Merck, Roche Diagnostics, T3D Therapeutics, and the Prion Alliance.

Paul P. Christopher, M.D. Department of Psychiatry & Human Behavior, Warren Alpert Medical School, Brown University. Reports no financial relationships with commercial interests.

Dr. Rakofsky is with the Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia. Dr. Rakofsky has received grant/research support from Acadia, Takeda, Janssen.

Suzanne Yang, M.D. Gary H. Wynn, M.D. Robert J. Ursano, M.D. Center for the Study of Traumatic Stress, Department of Psychiatry, Uniformed Services University. The authors report no financial relationships with commercial interests.

Daniel Rapport, University of Toledo, Psychiatry; Rusheet Thummalapally, University of Toledo; Joshua Delaney, JHS Miami. Reports no financial relationships with commercial interests.

American Psychiatric Association staff involved in planning report no financial relationships with commercial interests:

Tristan Gorrindo M.D.,  Director, Division of Education, American Psychiatric Association

Kristen Moeller, Director of CME, Associate Director of FOCUS, American Psychiatric Association

FOCUS Editorial Board disclosure is published on the editorial board page of each issue.

Hardware/Software Requirements

This internet-based CME activity is best experienced using Internet Explorer 8+, Mozilla Firefox 3+, Safari 4+. This Web site requires that JavaScript and session cookies be enabled. Certain activities may require additional software to view multimedia, presentation, or printable versions of the content. These activities will be marked as such and will provide links to the required software. That software may be: Adobe Flash, Adobe Acrobat, Microsoft PowerPoint, and Windows Media Player. 

Optimal System Configuration

  • Flash Player: Adobe Flash Player 10.1+ 
  • Browser: Firefox 3+, Internet Explorer 8.0+, Safari 4.0+, or Google Chrome 7.0+ 
  • Operating System: Windows XP+ or Mac OS X 10.4+ 
  • Internet Connection: 1 Mbps or higher

Minimum Requirements

Windows PC:
500-MHz Pentium II; Windows XP or higher; 128 MB RAM; Video Card at least 64MB of video memory; Sound Card at least 16-bit; Macromedia Flash Player 10 or higher, audio playback with speakers for programs with video content; Firefox 1.1+, Internet Explorer 7.0+, Safari 1.0+, Google Chrome, or Opera

Mac OS X 10.3 or higher with latest updates installed; 1.83MHz Intel Core Duo or faster; RAM: 128MB or more; Video Card: at least 64MB of video memory; Sound Card: at least 16-bit

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